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When compared with clear aligners that are made of off-the-shelf, single-layer .030-inch material.

 In a study by Miller et al., with adults measuring pain in the first week of treatment.

 With weekly aligner changes, compared with two-week aligner wear Invisalign and the Invisalign logo, among others, are trademarks of Align Technology, Inc., and are registered in the U.S. and other countries.

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